Motor cortical networks for skilled movements have dynamic properties that are related to accurate reaching
Name
Brown-Motor Cortical Networks for SkilledMovements.pdf
Size
2.3 MB
Format
Adobe PDF
Checksum (MD5)
41e98a6af98a02893bc243a8b16a816b
Author(s)
Putrino, David F.
Chen, Zhe
Ghosh, Soumya
Brown, Emery N.
Date Issued
August 2011
Journal
Neural Plasticity
Publisher
Hindawi Pub. Corp.
Citation
Putrino, David F. et al. “Motor Cortical Networks for Skilled Movements Have Dynamic Properties That Are Related to Accurate Reaching.” Neural Plasticity 2011 (2011): 1–15.
Version
Final published version
Abstract
Neurons in the Primary Motor Cortex (MI) are known to form functional ensembles with one another in order to produce voluntary movement. Neural network changes during skill learning are thought to be involved in improved fluency and accuracy of motor tasks. Unforced errors during skilled tasks provide an avenue to study network connections related to motor learning. In order to investigate network activity in MI, microwires were implanted in the MI of cats trained to perform a reaching task. Spike trains from eight groups of simultaneously recorded cells (95 neurons in total) were acquired. A point process generalized linear model (GLM) was developed to assess simultaneously recorded cells for functional connectivity during reaching attempts where unforced errors or no errors were made. Whilst the same groups of neurons were often functionally connected regardless of trial success, functional connectivity between neurons was significantly different at fine time scales when the outcome of task performance changed. Furthermore, connections were shown to be significantly more robust across multiple latencies during successful trials of task performance. The results of this study indicate that reach-related neurons in MI form dynamic spiking dependencies whose temporal features are highly sensitive to unforced movement errors.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1155/2011/413543
