High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
Name
Fujimoto-High Speed Optical.pdf
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12.38 MB
Format
Adobe PDF
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Author(s)
Aguirre, Aaron Dominic
Sawinski, Juergen
Huang, Shu-Wei
Zhou, Chao
Denk, Winfried
Fujimoto, James G.
Date Issued
February 2010
Journal
Optics Express
Publisher
Optical Society of America
Citation
Aguirre, Aaron D. et al. “High Speed Optical Coherence Microscopy with Autofocus Adjustment and a Miniaturized Endoscopic Imaging Probe.” Optics Express 18.5 (2010): 4222.
Version
Author's final manuscript
Abstract
Optical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 µm axial and < 2 µm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro-optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto-focusing feature that enables precise, near real-time alignment of the confocal and coherence gates in tissue, allowing user-friendly optimization of image quality during the imaging procedure. Ex vivo cellular images of human esophagus, colon, and cervix as well as in vivo results from human skin are presented. Finally, the system design is demonstrated with a miniaturized piezoelectric fiber-scanning probe which can be adapted for laparoscopic and endoscopic imaging applications.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1364/OE.18.004222
