Wnt Signaling and the Polarity of the Primary Body Axis
Name
Petersen-2009-Wnt Signaling and th.pdf
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1.7 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Petersen, Christian P.
Reddien, Peter
Date Issued
December 2009
Journal
Cell
Publisher
Elsevier
Citation
Petersen, Christian P., and Peter W. Reddien. “Wnt Signaling and the Polarity of the Primary Body Axis.” Cell 139, no. 6 (December 2009): 1056–1068. © 2009 Elsevier Inc.
Version
Final published version
Abstract
How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through β-catenin controls posterior identity during body plan formation in most bilaterally symmetric animals. Wnt signaling also influences primary axis polarity of pre-bilaterian animals, indicating that an axial patterning role for Wnt signaling predates the evolution of bilaterally symmetric animals. The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2009.11.035
