Trial Outcome and Associative Learning Signals in the Monkey Hippocampus
Name
Brown-Trial outcome and associative learning signals in the monkey hippocampus.pdf
Size
2.12 MB
Format
Adobe PDF
Checksum (MD5)
043c12187f3e76826b2b284451a85234
Author(s)
Wirth, Sylvia
Avsar, Emin
Chiu, Cindy C.
Sharma, Varun
Smith, Anne C.
Brown, Emery N.
Suzuki, Wendy A.
Date Issued
March 2009
Journal
Neuron
Publisher
Elsevier B.V.
Citation
Wirth, Sylvia et al. “Trial Outcome and Associative Learning Signals in the Monkey Hippocampus.” Neuron 61.6 (2009): 930–940.
Version
Author's final manuscript
Abstract
In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded associations and modify incorrect/unrewarded ones. To study how hippocampal neurons convey information about reward and trial outcome during new associative learning, we recorded hippocampal neurons as monkeys learned novel object-place associations. A large population of hippocampal neurons (50%) signaled trial outcome by differentiating between correct and error trials during the period after the behavioral response. About half these cells increased their activity following correct trials (correct up cells) while the remaining half fired more following error trials (error up cells). Moreover, correct up cells, but not error up cells, conveyed information about learning by increasing their stimulus-selective response properties with behavioral learning. These findings suggest that information about successful trial outcome conveyed by correct up cells may influence new associative learning through changes in the cell's stimulus-selective response properties.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2009.01.012
