Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions
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Buchwald_Synthesis of unsymmetrical.pdf
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Author(s)
Breitler, Simon
Oldenhuis, Nathan J.
Fors, Brett P.
Buchwald, Stephen Leffler
Date Issued
May 2011
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Breitler, Simon, Nathan J. Oldenhuis, Brett P. Fors, and Stephen L. Buchwald. “Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions.” Organic Letters 13, no. 12 (June 17, 2011): 3262-3265.
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Author's final manuscript
Abstract
A facile synthesis of unsymmetrical N,N′-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation–deprotection protocol, followed by a second arylation.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol201210t
