Pyruvate as a Pivot Point for Oncogene-Induced Senescence
Name
Vander Heiden_Pyruvate as.pdf
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370.48 KB
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Author(s)
Olenchock, Benjamin
Vander Heiden, Matthew G.
Date Issued
June 2013
Journal
Cell
Publisher
Elsevier
Citation
Olenchock, Benjamin A., and Matthew G. Vander Heiden. “Pyruvate as a Pivot Point for Oncogene-Induced Senescence.” Cell 153, no. 7 (June 2013): 1429–1430.
Version
Author's final manuscript
Abstract
Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2013.06.001
