Self-Folding Hybrid Graphene Skin for 3D Biosensing
Name
nihms-1018530.pdf
Description
Accepted version
Size
2.39 MB
Format
Adobe PDF
Checksum (MD5)
4d7156e1a4953085f0dcf285e32147e3
Author(s)
Buehler, Markus J
Barman, Ishan
Gracias, David H.
Date Issued
March 2019
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Xu, Weinan et al. “Self-Folding Hybrid Graphene Skin for 3D Biosensing” Nano Letters, vol. 19, no. 3, 2019, pp. 1409-1417 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Biological samples such as cells have complex three-dimensional (3D) spatio-molecular profiles and often feature soft and irregular surfaces. Conventional biosensors are based largely on 2D and rigid substrates, which have limited contact area with the entirety of the surface of biological samples making it challenging to obtain 3D spatially resolved spectroscopic information, especially in a label-free manner. Here, we report an ultrathin, flexible skinlike biosensing platform that is capable of conformally wrapping a soft or irregularly shaped 3D biological sample such as a cancer cell or a pollen grain, and therefore enables 3D label-free spatially resolved molecular spectroscopy via surface-enhanced Raman spectroscopy (SERS). Our platform features an ultrathin thermally responsive poly(N-isopropylacrylamide)-graphene-nanoparticle hybrid skin that can be triggered to self-fold and wrap around 3D micro-objects in a conformal manner due to its superior flexibility. We highlight the utility of this 3D biosensing platform by spatially mapping the 3D molecular signatures of a variety of microparticles including silica microspheres, spiky pollen grains, and human breast cancer cells.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ACS.NANOLETT.8B03461
