Modeling chromosomes: Beyond pretty pictures
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nihms727563.pdf
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Author(s)
Imakaev, Maksim Viktorovich
Fudenberg, Geoffrey
Mirny, Leonid A
Date Issued
September 2015
Journal
FEBS Letters
Publisher
Elsevier
Citation
Imakaev, Maxim V. et al. “Modeling Chromosomes: Beyond Pretty Pictures.” FEBS Letters 589, 20 (September 2015): 3031–3036 © 2015 Federation of European Biochemical Societies
Version
Author's final manuscript
Abstract
Recently, Chromosome Conformation Capture (3C) based experiments have highlighted the importance of computational models for the study of chromosome organization. In this review, we propose that current computational models can be grouped into roughly four classes, with two classes of data-driven models: consensus structures and data-driven ensembles, and two classes of de novo models: structural ensembles and mechanistic ensembles. Finally, we highlight specific questions mechanistic ensembles can address.
MIT Department
Institute for Medical Engineering and Science
Massachusetts Institute of Technology. Department of Physics
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1016/J.FEBSLET.2015.09.004
