Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow
Name
Jensen_Kinetics analysis.pdf
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3.03 MB
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Adobe PDF
Checksum (MD5)
a53cae2af409e99526ff86dca3a515c3
Author(s)
Moore, Jason Stuart
Smith, Christopher D
Jensen, Klavs F
Date Issued
February 2016
Journal
Reaction Chemistry & Engineering
Publisher
Royal Society of Chemistry, The
Citation
Moore, Jason S.; Smith, Christopher D. and Jensen, Klavs F. “Kinetics Analysis and Automated Online Screening of Aminocarbonylation of Aryl Halides in Flow.” Reaction Chemistry & Engineering 1, 3 (2016): 272–279 © 2016 The Royal Society of Chemistry
Version
Final published version
Abstract
Temperature, pressure, gas stoichiometry, and residence time were varied to control the yield and product distribution of the palladium-catalyzed aminocarbonylation of aromatic bromides in both a silicon microreactor and a packed-bed tubular reactor. Automation of the system set points and product sampling enabled facile and repeatable reaction analysis with minimal operator supervision. It was observed that the reaction was divided into two temperature regimes. An automated system was used to screen steady-state conditions for offline analysis by gas chromatography to fit a reaction rate model. Additionally, a transient temperature ramp method utilizing online infrared analysis was used, leading to more rapid determination of the reaction activation energy of the lower temperature regimes. The entire reaction spanning both regimes was modeled in good agreement with the experimental data.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution 3.0 Unported licence
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DOI of Published Version
https://doi.org/10.1039/c6re00007j
