Successful Execution of Working Memory Linked to Synchronized High-Frequency Gamma Oscillations
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Tone6Yamamoto et al Final.pdf
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Author(s)
Yamamoto, Jun
Suh, Junghyup
Takeuchi, Daigo
Tonegawa, Susumu
Date Issued
April 2014
Journal
Cell
Publisher
Elsevier B.V.
Citation
Yamamoto, Jun, Junghyup Suh, Daigo Takeuchi, and Susumu Tonegawa. “Successful Execution of Working Memory Linked to Synchronized High-Frequency Gamma Oscillations.” Cell 157, no. 4 (May 2014): 845-857.
Version
Author's final manuscript
Abstract
Neuronal oscillations have been hypothesized to play an important role in cognition and its ensuing behavior, but evidence that links a specific neuronal oscillation to a discrete cognitive event is largely lacking. We measured neuronal activity in the entorhinal-hippocampal circuit while mice performed a reward-based spatial working memory task. During the memory retention period, a transient burst of high gamma synchronization preceded an animal’s correct choice in both prospective planning and retrospective mistake correction, but not an animal’s incorrect choice. Optogenetic inhibition of the circuit targeted to the choice point area resulted in a coordinated reduction in both high gamma synchrony and correct execution of a working-memory-guided behavior. These findings suggest that transient high gamma synchrony contributes to the successful execution of spatial working memory. Furthermore, our data are consistent with an association between transient high gamma synchrony and explicit awareness of the working memory content.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2014.04.009
