Microstimulation of primate neocortex targeting striosomes induces negative decision-making
Name
Amemori S et al (2019) Euro J Neurosci[1].pdf
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4.01 MB
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Author(s)
Amemori, Satoko
Amemori, Ken-ichi
Yoshida, Tomoko
Papageorgiou, Georgios
Xu, Rui
Shimazu, Hideki
Desimone, Robert
Graybiel, Ann M
Date Issued
August 2019
Journal
European Journal of Neuroscience
Publisher
Wiley
Citation
Amemori, Satoko et al. "Microstimulation of primate neocortex targeting striosomes induces negative decision‐making." European Journal of Neuroscience (August 2019): 1-11 © 2019 Federation of European Neuroscience Societies
Version
Author's final manuscript
Abstract
Affective judgment and decision-making are strongly modulated by the pregenual anterior cingulate (pACC) and caudal orbitofrontal (cOFC) cortical regions. By combining MRI-guided electrical microstimulation with viral tracing methods in non-human primates, we demonstrate that circumscribed pACC and cOFC microstimulation sites that induce negative decision-making preferentially project to striosomes in the anterior striatum. These results outline a behaviorally important circuit from pACC/cOFC to striosomes causally modulating decision-making under emotional conflict. Keywords: anterior cingulate cortex; approach–avoidance; microstimulation; orbitofrontal cortex; striatum
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1111/ejn.14555
