NetworKIN: a resource for exploring cellular phosphorylation networks
Name
Linding-2008-NetworKIN.pdf
Size
2.51 MB
Format
Adobe PDF
Checksum (MD5)
eb71efb62ba19c78422d874a0ce834ad
Author(s)
Jensen, Lars Juhl
Pasculescu, Adrian
Olhovsky, Marina
Colwill, Karen
Bork, Peer
Pawson, Tony
Linding, Rune
Yaffe, Michael B
Date Issued
November 2007
Journal
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Citation
Linding, R. et al. “NetworKIN: a Resource for Exploring Cellular Phosphorylation Networks.” Nucleic Acids Research 36.Database (2007): D695–D699. Web. 1 June 2012.
Version
Final published version
Abstract
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically assigning all 518 human kinases to all these sites is a challenging problem. The NetworKIN database (http://networkin.info) integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase–substrate relations. Based on the latest human phosphoproteome from the Phospho.ELM and PhosphoSite databases, the resource offers insight into phosphorylation-modulated interaction networks. Here, we describe how NetworKIN can be used for both global and targeted molecular studies. Via the web interface users can query the database of precomputed kinase–substrate relations or obtain predictions on novel phosphoproteins. The database currently contains a predicted phosphorylation network with 20 224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution Non-Commercial
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1093/nar/gkm902
