Injectable polymer for in vivo oxygen sensing
Name
844773321-MIT.pdf
Description
Full printable version
Size
8.94 MB
Format
Adobe PDF
Checksum (MD5)
f50b5afc25098260a0d38aa86b9a5087
Author(s)
Imaad, Syed M. (Syed Muhammad)
Advisor(s)
Michael J. Cima.
Date Issued
2013
Publisher
Massachusetts Institute of Technology
Abstract
This thesis documents the synthesis and characterization of an elastomeric polymer that is oxygen sensitive and can be interrogated using Magnetic Resonance Imaging (MRI) or Magnetic Resonance (MR) technology to report the oxygen tension in vivo at the site of implant. The polymer was tested for its sensitivity in response to oxygen, and the specificity of response to oxygen was verified. Oxygen diffusivity for this class of polymers was measured and correlated with the response sensitivity to oxygen to provide a possible explanation for the difference in response sensitivities within this class of polymers. Animal experiments were carried out in rats to test the performance of these sensors in vivo where device response to varying levels of inspired oxygen was monitored.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, February 2013.
"February 2013." Cataloged from PDF version of thesis.
Includes bibliographical references (p. 57-60).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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