Rapid translocation of nanoparticles from the lung airspaces to the body
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Bawendi_Rapid translocation.pdf
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1.16 MB
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Author(s)
Choi, Hak Soo
Ashitate, Yoshitomo
Lee, Jeong Heon
Kim, Soon Hee
Matsui, Aya
Insin, Numpon
Bawendi, Moungi G.
Semmler-Behnke, Manuela
Frangioni, John V.
Tsuda, Akira
Date Issued
November 2010
Journal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
Choi, Hak Soo et al. “Rapid Translocation of Nanoparticles from the Lung Airspaces to the Body.” Nature Biotechnology 28.12 (2010): 1300–1303.
Version
Author's final manuscript
Abstract
Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes. Nanoparticles of HD < 6 nm can traffic rapidly from the lungs to lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys. We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nbt.1696
