Design of experimental setup for identification of parameters for optimal aerosolization of measles vaccine
Name
560377670-MIT.pdf
Description
Full printable version
Size
2.45 MB
Format
Adobe PDF
Checksum (MD5)
be2fef2edfa5249033038bc1a154d30d
Author(s)
Nicholson, Laura A. (Laura Ann)
Advisor(s)
John Kim Vandiver.
Date Issued
2009
Publisher
Massachusetts Institute of Technology
Abstract
Given the pressing worldwide need for measles vaccination coverage, measles vaccine administration via inhalation is a viable option which overcomes many obstacles currently facing vaccine distribution. Although aerosolization is well understood, studies have focused on pharmaceuticals and very little data is available regarding vaccines. The proposed study analyzes the relationships between various pre- and post-aerosolization parameters in order to calculate the "aerosol fingerprint," or combination of pre-aerosolization parameters optimized to produce the most effective aerosol particle size distribution for measles vaccination. Relevant pre-aerosolization parameters are identified as relative humidity, nebulizer temperature, vaccine reconstitution, solution pH, surface tension, viscosity, air pressure, and nebulizer geometry. Relevant post-aerosolization parameters are identified particle size distribution, aerosolization endurance and bioavailability, and drug delivery rate. Sensing, actuation, automation and special concerns for each variable are considered.
Description
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 29).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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