Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation
Name
nihms790876.pdf
Size
2.36 MB
Format
Adobe PDF
Checksum (MD5)
5ef285ee21f61207b49e9c4e120fdd52
Author(s)
Nieh, Horng-An Edward
Vander Weele, Caitlin Miya
Matthews, Gillian Ac
Presbrey, Kara N.
Wichmann, Romy
Leppla, Christopher Albert
Izadmehr, Ehsan
Tye, Kay M
Date Issued
May 2016
Journal
Neuron
Publisher
Elsevier/Cell Press
Citation
Nieh, Edward H. et al. “Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation.” Neuron 90, 6 (June 2016): 1286–1298 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
Projections from the lateral hypothalamus (LH) to the ventral tegmental area (VTA), containing both GABAergic and glutamatergic components, encode conditioned responses and control compulsive reward-seeking behavior. GABAergic neurons in the LH have been shown to mediate appetitive and feeding-related behaviors. Here we show that the GABAergic component of the LH-VTA pathway supports positive reinforcement and place preference, while the glutamatergic component mediates place avoidance. In addition, our results indicate that photoactivation of these projections modulates other behaviors, such as social interaction and perseverant investigation of a novel object. We provide evidence that photostimulation of the GABAergic LH-VTA component, but not the glutamatergic component, increases dopamine (DA) release in the nucleus accumbens (NAc) via inhibition of local VTA GABAergic neurons. Our study clarifies how GABAergic LH inputs to the VTA can contribute to generalized behavioral activation across multiple contexts, consistent with a role in increasing motivational salience.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NEURON.2016.04.035
