The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia
Name
mbio.01577-22.pdf
Description
Published version
Size
3.73 MB
Format
Adobe PDF
Checksum (MD5)
55bc18715bb6cea2600f4034e86d5f31
Author(s)
Wang, Chuangqi
Li, Yijia
Kaplonek, Paulina
Gentili, Matteo
Fischinger, Stephanie
Bowman, Kathryn A
Sade-Feldman, Moshe
Kays, Kyle R
Regan, James
Flynn, James P
Date Issued
2022
Journal
mBio
Publisher
American Society for Microbiology
Citation
Wang, Chuangqi, Li, Yijia, Kaplonek, Paulina, Gentili, Matteo, Fischinger, Stephanie et al. 2022. "The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia." mBio, 13 (4).
Version
Final published version
Abstract
We showed that persistent SARS-CoV-2 RNAemia is an independent predictor of severe COVID-19. We observed that SARS-CoV-2-targeted antibody maturation, specifically Fc-effector functions rather than neutralization, was strongly linked with the ability to rapidly clear viremia.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1128/MBIO.01577-22
