The importance of serine metabolism in cancer
Name
Mattaini-The importance of se.pdf
Size
1.2 MB
Format
Adobe PDF
Checksum (MD5)
c845c4c791f92b733d2305910f4bd43b
Author(s)
Mattaini, Katherine Ruth
Sullivan, Mark Robert
Vander Heiden, Matthew G.
Date Issued
July 2016
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press
Citation
Mattaini, Katherine R., Mark R. Sullivan, and Matthew G. Vander Heiden. “The Importance of Serine Metabolism in Cancer.” The Journal of Cell Biology 214, no. 3 (July 25, 2016): 249–257.
Version
Final published version
Abstract
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1083/jcb.201604085
