Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis
Name
nihms-1543758.pdf
Description
Accepted version
Size
1.92 MB
Format
Adobe PDF
Checksum (MD5)
846f4861fa47de892d815e50229f7e23
Author(s)
Yehl, Kevin
Lemire, Sébastien
Yang, Andrew C
Ando, Hiroki
Mimee, Mark
Torres, Marcelo Der Torossian
de la Fuente-Nunez, Cesar
Lu, Timothy K
Date Issued
2019
Journal
Cell
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2019 Elsevier Inc. Bacteriophage libraries containing millions of variants of phage tail fiber motifs on a common structural scaffold give rise to infectious phages with expanded or altered host ranges, which may be useful for phage therapy efforts.
MIT Department
Massachusetts Institute of Technology. Synthetic Biology Center
Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.CELL.2019.09.015
https://doi.org/10.1016/J.CELL.2019.09.015
