Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression
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1707.00746.pdf
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1.31 MB
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Author(s)
Seager, R J
Zaman, Muhammad H
Hajal, Cynthia
Spill, Fabian
Kamm, Roger Dale
Date Issued
July 2017
Journal
Convergent Science Physical Oncology
Publisher
IOP Publishing
Citation
Seager, R J et al. “Dynamic Interplay Between Tumour, Stroma and Immune System Can Drive or Prevent Tumour Progression.” Convergent Science Physical Oncology 3, 3 (July 2017): 034002 © 2017 IOP Publishing Ltd
Version
Author's final manuscript
Abstract
In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour progression, can be reprogrammed by tumour cells to be ineffective, inactivated, or even acquire tumour promoting phenotypes. Likewise, stromal cells and extracellular matrix can also have pro-and anti-tumour properties. However, there is strong evidence that the stroma and immune system also directly interact, therefore creating a tripartite interaction that exists between cancer cells, immune cells and tumour stroma. This interaction contributes to the maintenance of a chronically inflamed tumour microenvironment with pro-tumorigenic immune phenotypes and facilitated metastatic dissemination. A comprehensive understanding of cancer in the context of dynamical interactions of the immune system and the tumour stroma is therefore required to truly understand the progression toward and past malignancy. Keywords: cancer; microenvironment; mechanical; extracellular matrix; macrophage; T cell; fibroblast
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1088/2057-1739/AA7E86
