Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response
Name
Vacanti-2012-Localized Delivery of Dexamethasone from.pdf
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1.99 MB
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Author(s)
Vacanti, Nathaniel M.
Cheng, Hao
Hill, Paulina Sierpinski
Guerreiro, Joao D. T.
Dang, Tram T.
Ma, Minglin
Watson, Shanee
Hwang, Nathaniel S.
Langer, Robert
Anderson, Daniel Griffith
Date Issued
August 2012
Journal
Biomacromolecules
Publisher
American Chemical Society
Citation
Vacanti, Nathaniel M., Hao Cheng, Paulina S. Hill, et al. 2012 Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response. Biomacromolecules 13(10): 3031–3038. © 2012 American Chemical Society.
Version
Final published version
Abstract
Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(l-lactic) acid (PLLA) and poly(ε-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/bm300520u
