Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols
Name
nihms946250.pdf
Description
Accepted version
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1.66 MB
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Checksum (MD5)
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Author(s)
Zhang, Hong
Ruiz-Castillo, Paula
Buchwald, Stephen Leffler
Date Issued
March 2018
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Zhang, Hong, Paula Ruiz-Castillo, and Stephen L. Buchwald. "Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols." Organic Letters 20, 6 (Mar. 2018): p. 1580-83 doi 10.1021/ACS.ORGLETT.8B00325 ©2018 Author(s)
Version
Author's final manuscript
Abstract
Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ACS.ORGLETT.8B00325
