The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Name
1-s2.0-S1534580719301789-main.pdf
Description
Published version
Size
3.55 MB
Format
Adobe PDF
Checksum (MD5)
122f1f489fab14b033b442a60748c253
Author(s)
Regev, Aviv
Date Issued
April 2019
Journal
Developmental Cell
Publisher
Elsevier BV
Citation
Taylor, Deanne M. et al. “The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.” Developmental Cell 49 (2019): 10-29 © 2019 The Author(s)
Version
Final published version
Abstract
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
Subjects
Developmental Biology
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.devcel.2019.03.001
