H2A.Z: a molecular rheostat for transcriptional control
Name
Boyer_H2A.Z.pdf
Size
1.96 MB
Format
Adobe PDF
Checksum (MD5)
38d9d6603d81ea324b91ec281d982492
Author(s)
Subramanian, Vidya
Fields, Paul A.
Boyer, Laurie Ann
Date Issued
January 2015
Journal
F1000Prime Reports
Publisher
Faculty of 1000, Ltd.
Citation
Subramanian, Vidya, Paul A. Fields, and Laurie A. Boyer. “H2A.Z: a Molecular Rheostat for Transcriptional Control.” F1000Prime Reports 7 (January 5, 2015). © 2015 Faculty of 1000 Ltd
Version
Final published version
Abstract
The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostat for gene control. We focus on specific examples in metazoans as a model for understanding how H2A.Z integrates information from histone post-translational modifications, other histone variants, and transcription factors (TFs) to regulate proper induction of gene expression programs in response to cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatin states in diverse processes.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution Non Commercial
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DOI of Published Version
https://doi.org/10.12703/P7-01
