Modularity, context-dependence, and insulation in engineered biological circuits
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Del Vecchio_Modularity.pdf
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679.57 KB
Format
Adobe PDF
Checksum (MD5)
a76c24f6d96b0484308aade2ae5f328c
Author(s)
Del Vecchio, Domitilla
Date Issued
February 2015
Journal
Trends in Biotechnology
Publisher
Elsevier
Citation
Del Vecchio, Domitilla. “Modularity, Context-Dependence, and Insulation in Engineered Biological Circuits.” Trends in Biotechnology 33.2 (2015): 111–119.
Version
Author's final manuscript
Abstract
The ability to link systems together such that they behave as predicted once they interact with each other is an essential requirement for the forward-engineering of robust synthetic biological circuits. Unfortunately, because of context-dependencies, parts and functional modules often behave unpredictably once interacting in the cellular environment. This paper reviews recent advances toward establishing a rigorous engineering framework for insulating parts and modules from their context to improve modularity. Overall, a synergy between engineering better parts and higher-level circuit design will be important to resolve the problem of context-dependence.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.tibtech.2014.11.009
