The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP
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Govindarajan-2011-The Dendritic Branch.pdf
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Author(s)
Govindarajan, Arvind
Israely, Inbal
Tonegawa, Susumu
Huang, Shu Ying
Date Issued
January 2011
Journal
Neuron
Publisher
Elsevier
Citation
Govindarajan, Arvind, Inbal Israely, Shu-Ying Huang, and Susumu Tonegawa. “The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP.” Neuron 69, no. 1 (January 2011): 132–146. © 2011 Elsevier Inc.
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Final published version
Abstract
The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2010.12.008
