Microfluidics: A New Tool for Modeling Cancer–Immune Interactions
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Kamm_Microfluidics.pdf
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1.09 MB
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Author(s)
Wong, Siew Cheng
Boussommier, Alexandra
Li, Ran
Chen, Michelle B
Kamm, Roger Dale
Date Issued
January 2016
Journal
Trends in Cancer
Publisher
Elsevier
Citation
Boussommier-Calleja, Alexandra et al. “Microfluidics: A New Tool for Modeling Cancer–Immune Interactions.” Trends in Cancer 2, 1 (January 2016): 6–19 © 2015 Elsevier Inc
Version
Author's final manuscript
Abstract
In recognition of the enormous potential of immunotherapies against cancer, research into the interactions between tumor and immune cells has accelerated, leading to the recent FDA approval of several drugs that reduce cancer progression. Numerous cellular and molecular interactions have been identified by which immune cells can intervene in the metastatic cascade, leading to the development of several in vivo and in vitro model systems that can recapitulate these processes. Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring. Here, we review current assays and discuss the development of new microfluidic technologies for immunotherapy. Keywords
microfluidics
immunotherapy
metastatic cancer
drug screening
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.TRECAN.2015.12.003
