Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomography
Name
Tanaka-2010-Challenges on the fr.pdf
Size
667.59 KB
Format
Adobe PDF
Checksum (MD5)
643f9413f97459c0889a7a5f61c626ad
Author(s)
Tanaka, Atsushi
Tearney, Guillermo J.
Bouma, Brett E.
Date Issued
March 2010
Journal
Journal of Biomedical Optics
Publisher
Society of Photo-optical Instrumentation Engineers
Citation
Tanaka, Atsushi, Guillermo J. Tearney, and Brett E. Bouma. “Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomography.” Journal of Biomedical Optics 15.1 (2010): 011104-8. ©2010 Society of Photo-Optical Instrumentation Engineers.
Version
Final published version
Abstract
Cellularity of the fibrous caps of coronary atheromas, manifested by the infiltration of macrophages (average size, 20 to 30 [micrometer]), is thought to weaken the structural integrity of the cap and predispose plaques to rupture. Therefore, an imaging technology capable of identifying macrophages within fibroatheroma caps in patients could provide valuable information for assessing plaque rupture risk. Recently, intravascular optical coherence tomography (OCT), a high-resolution coronary imaging modality, with an axial resolution of ~10 [micrometer], has been introduced into the clinical setting. OCT images of the microstructure of the coronary artery wall enable accurate plaque-type characterization, supported by histopathological comparison data. Because of its high resolution, OCT may also be used to identify macrophages in vivo. In this paper we review recent developments in OCT for measuring macrophages in atherosclerotic plaques.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1117/1.3290810
