Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions
Name
Smith-2010-Bidirectional ocular dominance plasticity of inhibitory networks.pdf
Size
2.09 MB
Format
Adobe PDF
Checksum (MD5)
d18e7f29a16672a8f5934bde14182a44
Author(s)
Smith, Gordon B.
Bear, Mark
Date Issued
June 2010
Journal
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media S.A.
Citation
Smith, Gordon B. and Mark F. Bear. "Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions." Frontiers in Cellular Neuroscience (2010) 4:21.
Version
Final published version
Abstract
Monocular visual deprivation (MD) produces profound changes in the ocular dominance (OD) of neurons in the visual cortex. MD shifts visually evoked responses away from the deprived eye and toward domination by the open-eye. Over 30 years ago, two different theories were proposed to account for these changes: either through effects on excitatory visual drive, thereby shifting the balance of excitation in favor of the open-eye, or through effects on intracortical inhibition, thereby suppressing responses from the deprived eye. In the intervening years, a scientific consensus emerged that the major functional effects of MD result from plasticity at excitatory connections in the visual cortex. A recent study by Yazaki-Sugiyama et al. (2009) in mouse visual cortex appears to re-open the debate. Here we take a critical look at these intriguing new data in the context of other recent findings in rodent visual cortex.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fncel.2010.00021
