Economics of Beta-Cell Replacement Therapy
Name
11892_2019_1203_ReferencePDF.pdf
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856.66 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Bandeiras, Cátia
Hwa, Albert J.
Cabral, Joaquim M. S.
Ferreira, Frederico Castelo
Finkelstein, Stan Neil
Gabbay, Robert A.
Date Issued
August 2019
Journal
Current Diabetes Reports
Publisher
Springer Science and Business Media LLC
Citation
Bandeiras, Cátia et al. "Economics of Beta-Cell Replacement Therapy." Current Diabetes Reports 19, 9 (August 2019): 75 © 2019 Springer Science Business Media, LLC
Version
Author's final manuscript
Abstract
Purpose of Review: Type 1 diabetes impacts 1.3 million people in the USA with a total direct lifetime medical cost of $133.7 billion. Management requires a mix of daily exogenous insulin administration and frequent glucose monitoring. Decision-making by the individual can be burdensome. Recent Findings: Beta-cell replacement, which involves devices protecting cells from autoimmunity and allo-rejection, aims at restoring physiological glucose regulation and improving clinical outcomes in patients. Given the significant burden of T1D in the healthcare systems, cost-effectiveness analyses can drive innovation and policymaking in the area. Summary: This review presents the health economics analyses performed for donor-derived islet transplantation and the possible outcomes of stem cell-derived beta cells. Long-term cost-effectiveness of islet transplantation depends on the engraftment of these transplants, and the expenses and thresholds assumed by healthcare systems in different countries. Early health technology assessment analyses for stem cell-derived beta-cell replacement suggest manufacturing optimization is necessary to reduce upfront costs.
MIT Department
Massachusetts Institute of Technology. Institute for Data, Systems, and Society
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s11892-019-1203-9
