Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research
Name
nihms-1595822.pdf
Description
Accepted version
Size
1.01 MB
Format
Adobe PDF
Checksum (MD5)
459749b016dd57532265058b5509492c
Author(s)
Parviz, Dorsa
Bitounis, Dimitrios
Demokritou, Philip
Strano, Michael
Date Issued
2020
Journal
NanoImpact
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2020 Elsevier B.V. Emerging, two-dimensional engineered nanomaterials (2DNMs) possess unique and diverse physical and chemical properties, such as extreme aspect ratios, adjustable electronic properties as well as functional lattice defects and surface chemistry which underpin their interactions with biological systems. This perspective highlights the need for structure activity relationship (SAR) studies for key properties of emerging graphene-related and inorganic 2DNMs upon prioritization based on their potential impact and trajectory for large-scale production and applications. Further, it is discussed how a synthesis platform of microbiologically sterile, size-sorted, “model” 2DNMs with precise structure would enable SAR toxicological studies and allow for the sustainable and safe translation of 2D nanotechnology to real-world applications.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.IMPACT.2020.100226
