Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer
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sciadv.adj6380.pdf
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1.36 MB
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Checksum (MD5)
78863d4fe27103e595f992a60a2a9263
Author(s)
Alsaiari, Shahad K.
Nadeef, Seba
Daristotle, John L.
Rothwell, William
Du, Bujie
Garcia, Johnny
Zhang, Linzixuan
Sarmadi, Morteza
Forster, Timothy A.
Menon, Nandita
Date Issued
March 8, 2024
Journal
Science Advances
Publisher
American Association for the Advancement of Science
Citation
Shahad K. Alsaiari et al. ,Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Sci. Adv.10,eadj6380(2024).
Version
Final published version
Abstract
Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework–8 (ZIF-8). The accumulation of ZIF-8 in endosomes and the pH-responsive release of its subunits enable selective engagement with endosomal Toll-like receptors, minimizing the risk of off-target activation. The intrinsic adjuvant properties of ZIF-8, along with the efficient delivery and biomimetic presentation of a severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain trimer, primed rapid humoral and cell-mediated immunity in a dose-sparing manner. Our study offers insights for next-generation adjuvants that can potentially impact future vaccine development.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1126/sciadv.adj6380
