SYK kinase mediates brown fat differentiation and activation
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Author(s)
Knoll, Marko
Winther, Sally
Natarajan, Anirudh
Yang, Huan
Jiang, Mengxi
Thiru, Prathapan
Shahsafaei, Aliakbar
Chavarria, Tony E.
Lamming, Dudley W.
Sun, Lei
Date Issued
December 2017
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Knoll, Marko et al. “SYK Kinase Mediates Brown Fat Differentiation and Activation.” Nature Communications 8, 1 (December 2017) © 2017 The Author(s)
Version
Final published version
Abstract
Brown adipose tissue (BAT) metabolism influences glucose homeostasis and metabolic health in mice and humans. Sympathetic stimulation of β-adrenergic receptors in response to cold induces proliferation, differentiation, and UCP1 expression in pre-adipocytes and mature brown adipocytes. Here we show that spleen tyrosine kinase (SYK) is upregulated during brown adipocyte differentiation and activated by β-adrenergic stimulation. Deletion or inhibition of SYK, a kinase known for its essential roles in the immune system, blocks brown and white pre-adipocyte proliferation and differentiation in vitro, and results in diminished expression of Ucp1 and other genes regulating brown adipocyte function in response to β-adrenergic stimulation. Adipocyte-specific SYK deletion in mice reduces BAT mass and BAT that developed consisted of SYK-expressing brown adipocytes that had escaped homozygous Syk deletion. SYK inhibition in vivo represses β-agonist-induced thermogenesis and oxygen consumption. These results establish SYK as an essential mediator of brown fat formation and function.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/s41467-017-02162-3
