Transcriptional Addiction in Cancer
Name
Bradner_Cell_2017.pdf
Size
1.01 MB
Format
Adobe PDF
Checksum (MD5)
4c0e8d4eeebc0c065632660778e0fa5b
Author(s)
Bradner, James E.
Hnisz, Denes
Young, Richard A.
Date Issued
February 2017
Journal
Cell
Publisher
Elsevier
Citation
Bradner, James E. et al. “Transcriptional Addiction in Cancer.” Cell 168, 4 (February 2017): 629–643 © 2016 Elsevier
Version
Author's final manuscript
Abstract
Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2016.12.013
