Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation
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Anderson_Core-shell.pdf
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939.68 KB
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ec448ca89fda077557dd48c38477cfaf
Author(s)
Ma, Minglin
Chiu, Alan
Sahay, Gaurav
Doloff, Joshua C.
Dholakia, Nimit
Thakrar, Raj
Vegas, Arturo
Chen, Delai
Bratlie, Kaitlin M.
Dang, Tram T.
Date Issued
May 2013
Journal
Advanced Healthcare Materials
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Ma, Minglin, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, et al. “Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation.” Advanced Healthcare Materials 2, no. 5 (December 3, 2012): 667–672.
Version
Author's final manuscript
Abstract
Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adhm.201200341
