Frontal neurons modulate memory retrieval across widely varying temporal scales
Name
Zhang-2015-Frontal neurons modu.pdf
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995.67 KB
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Adobe PDF
Checksum (MD5)
44a87b57eee20ceca54bae17bd5bc05a
Author(s)
Zhang, Wen-Hua
Williams, Ziv
Date Issued
May 2015
Journal
Learning & Memory
Publisher
Cold Spring Harbor Laboratory Press
Citation
Zhang, Wen-Hua, and Ziv M. Williams. “Frontal Neurons Modulate Memory Retrieval Across Widely Varying Temporal Scales.” Learning & Memory 22, no. 6 (May 15, 2015): 299–306.
Version
Final published version
Abstract
Once a memory has formed, it is thought to undergo a gradual transition within the brain from short- to long-term storage. This putative process, however, also poses a unique problem to the memory system in that the same learned items must also be retrieved across broadly varying time scales. Here, we find that neurons in the ventrolateral prefrontal cortex (VLPFC) of monkeys, an area interconnected with both temporal and frontal associative neocortical regions, signaled the need to alter between retrieval of memories formed at different times. These signals were most closely related to the time interval between initial learning and later retrieval, and did not correlate with task switch demands, novelty, or behavioral response. Consistent with these physiological findings, focal inactivation of the VLPFC led to a marked degradation in retrieval performance. These findings suggest that the VLPFC plays a necessary regulatory role in retrieving memories over different temporal scales.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1101/lm.036806.114
