Cingulate-motor circuits update rule representations for sequential choice decisions
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s41467-022-32142-1.pdf
Description
Published version
Size
2.91 MB
Format
Adobe PDF
Checksum (MD5)
67253275e488b70e341a332bd5f83649
Author(s)
Takeuchi, Daigo
Roy, Dheeraj
Muralidhar, Shruti
Kawai, Takashi
Bari, Andrea
Lovett, Chanel
Sullivan, Heather A
Wickersham, Ian R
Tonegawa, Susumu
Date Issued
2022
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Takeuchi, Daigo, Roy, Dheeraj, Muralidhar, Shruti, Kawai, Takashi, Bari, Andrea et al. 2022. "Cingulate-motor circuits update rule representations for sequential choice decisions." Nature Communications, 13 (1).
Version
Final published version
Abstract
AbstractAnterior cingulate cortex mediates the flexible updating of an animal’s choice responses upon rule changes in the environment. However, how anterior cingulate cortex entrains motor cortex to reorganize rule representations and generate required motor outputs remains unclear. Here, we demonstrate that chemogenetic silencing of the terminal projections of cingulate cortical neurons in secondary motor cortex in the rat disrupts choice performance in trials immediately following rule switches, suggesting that these inputs are necessary to update rule representations for choice decisions stored in the motor cortex. Indeed, the silencing of cingulate cortex decreases rule selectivity of secondary motor cortical neurons. Furthermore, optogenetic silencing of cingulate cortical neurons that is temporally targeted to error trials immediately after rule switches exacerbates errors in the following trials. These results suggest that cingulate cortex monitors behavioral errors and updates rule representations in motor cortex, revealing a critical role for cingulate-motor circuits in adaptive choice behaviors.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/S41467-022-32142-1
