Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells
Name
Lippard_Peptide-based.pdf
Size
4.96 MB
Format
Adobe PDF
Checksum (MD5)
543fbc03a47e53a60572bba843a371b8
Author(s)
Radford, Robert J.
Chyan, Wen
Lippard, Stephen J.
Date Issued
May 2013
Journal
Chemical Science
Publisher
Royal Society of Chemistry, The
Citation
Radford, Robert J., Wen Chyan, and Stephen J. Lippard. “Peptide-Based Targeting of Fluorescent Zinc Sensors to the Plasma Membrane of Live Cells.” Chemical Science 4, no. 8 (2013): 3080. © 2013 Royal Society of Chemistry
Version
Author's final manuscript
Abstract
Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c3sc50974e
