Electrophysiological Signatures of Visual Recognition Memory across All Layers of Mouse V1
Name
7307.full.pdf
Description
Published version
Size
3.07 MB
Format
Adobe PDF
Checksum (MD5)
77fe6bdd8efb9ef17f23c3568f2e7f6e
Author(s)
Hayden, Dustin J
Finnie, Peter SB
Thomazeau, Aurore
Li, Alyssa Y
Cooke, Samuel F
Bear, Mark F
Date Issued
November 1, 2023
Journal
The Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Dustin J. Hayden, Peter S. B. Finnie, Aurore Thomazeau, Alyssa Y. Li, Samuel F. Cooke, Mark F. Bear
Journal of Neuroscience 1 November 2023, 43 (44) 7307-7321.
Version
Final published version
Abstract
In mouse primary visual cortex (V1), familiar stimuli evoke significantly altered responses when compared with novel stimuli. This stimulus-selective response plasticity (SRP) was described originally as an increase in the magnitude of visual evoked potentials (VEPs) elicited in layer 4 (L4) by familiar phase-reversing grating stimuli. SRP is dependent on NMDA receptors (NMDARs) and has been hypothesized to reflect potentiation of thalamocortical (TC) synapses in L4. However, recent evidence indicates that the synaptic modifications that manifest as SRP do not occur on L4 principal cells. To shed light on where and how SRP is induced and expressed in male and female mice, the present study had three related aims: (1) to confirm that NMDAR are required specifically in glutamatergic principal neurons of V1, (2) to investigate the consequences of deleting NMDAR specifically in L6, and (3) to use translaminar electrophysiological recordings to characterize SRP expression in different layers of V1. We find that knock-out (KO) of NMDAR in L6 principal neurons disrupts SRP. Current-source density (CSD) analysis of the VEP depth profile shows augmentation of short latency current sinks in layers 3, 4, and 6 in response to phase reversals of familiar stimuli. Multiunit recordings demonstrate that increased peak firing occurs in response to phase reversals of familiar stimuli across all layers, but that activity between phase reversals is suppressed. Together, these data reveal important aspects of the underlying phenomenology of SRP and generate new hypotheses for the expression of experience-dependent plasticity in V1.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1523/JNEUROSCI.0090-23.2023
