The Cellular Basis for Animal Regeneration
Name
Tanaka-2011-The Cellular Basis f.pdf
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719.52 KB
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Adobe PDF
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Author(s)
Tanaka, Elly M.
Reddien, Peter
Date Issued
July 2011
Journal
Developmental Cell
Publisher
Elsevier
Citation
Tanaka, Elly M., and Peter W. Reddien. “The Cellular Basis for Animal Regeneration.” Developmental Cell 21, no. 1 (July 2011): 172–185. © 2011 Elsevier Inc.
Version
Final published version
Abstract
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies—from pluripotent stem cells to tissue-specific stem cells and dedifferentiation—are utilized for regeneration.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.devcel.2011.06.016
