Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits
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Author(s)
Kohara, Keigo
Tonegawa, Susumu
Rivest, Alexander J.
Jung, Hae Yoon
Kitamura, Takashi
Suh, Junghyup
Frank, Dominic
Kajikawa, Koichiro
Mise, Nathan
Obata, Yuichi
Date Issued
December 2013
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Kohara, Keigo, Michele Pignatelli, Alexander J Rivest, Hae-Yoon Jung, Takashi Kitamura, Junghyup Suh, Dominic Frank, et al. “Cell Type–specific Genetic and Optogenetic Tools Reveal Hippocampal CA2 Circuits.” Nat Neurosci 17, no. 2 (December 15, 2013): 269–279.
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Author's final manuscript
Abstract
The formation and recall of episodic memory requires precise information processing by the entorhinal-hippocampal network. For several decades, the trisynaptic circuit entorhinal cortex layer II (ECII)right arrowdentate gyrusright arrowCA3right arrowCA1 and the monosynaptic circuit ECIIIright arrowCA1 have been considered the primary substrates of the network responsible for learning and memory. Circuits linked to another hippocampal region, CA2, have only recently come to light. Using highly cell type–specific transgenic mouse lines, optogenetics and patch-clamp recordings, we found that dentate gyrus cells, long believed to not project to CA2, send functional monosynaptic inputs to CA2 pyramidal cells through abundant longitudinal projections. CA2 innervated CA1 to complete an alternate trisynaptic circuit, but, unlike CA3, projected preferentially to the deep, rather than to the superficial, sublayer of CA1. Furthermore, contrary to existing knowledge, ECIII did not project to CA2. Our results allow a deeper understanding of the biology of learning and memory.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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DOI of Published Version
https://doi.org/10.1038/nn.3614
