Concurrent Connection of Embryonic Chick Heart Using a Microfluidic Device for Organ-Explant-Chip
Name
Owaki-2013-Concurrent Connectio.pdf
Size
1.52 MB
Format
Adobe PDF
Checksum (MD5)
5096711b9baf97f594379993d3501c7f
Author(s)
Owaki, Hirofumi
Masuda, Taisuke
Kawahara, Tomohiro
Miyasaka, Kota
Ogura, Toshihiko
Arai, Fumihito
Date Issued
January 2013
Journal
Procedia CIRP
Publisher
Elsevier
Citation
Owaki, Hirofumi, Taisuke Masuda, Tomohiro Kawahara, Kota Miyasaka, Toshihiko Ogura, and Fumihito Arai. “Concurrent Connection of Embryonic Chick Heart Using a Microfluidic Device for Organ-Explant-Chip.” Procedia CIRP 5 (January 2013): 205–209.
Version
Final published version
Abstract
We propose a concurrent microvascular connection method called suction-induced vascular fixation (SVF) method for the achievement of Organ-Explant-Chip which is a biologically-designed simulator having biological materials such as cells, tissues, and organs. The advantages of proposed method with using a microfluidic device are as follows: (1) operation of flexible objects (blood vessels), (2) alignment the blood vessels concurrently, and (3) reduction of the DOFs of the blood vessels. From the experimental results, we confirmed that four cardiovascular of the explanted embryonic chick heart can be induced into the fabricated microfluidic device concurrently. We have also succeeded in construction of hybrid circulatory system between artifacts and embryonic chick heart, and monitoring the response of the heart of chick embryo by supplying the culture medium.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.procir.2013.01.041
