3D-resolved targeting of photodynamic therapy using temporal focusing
Name
Rowlands_2014_Laser_Phys._Lett._11_115605.pdf
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1.28 MB
Format
Adobe PDF
Checksum (MD5)
eb5339723c50f0fed842c9048522226b
Author(s)
Klein, Oliver
Evans, Conor L
Rowlands, Christopher
Wu, Jacqueline J
Uzel, Sebastien GM
So, Peter T. C.
Date Issued
September 2014
Journal
Laser Physics Letters
Publisher
Wiley Blackwell
Citation
Rowlands, Christopher J et al. “3D-Resolved Targeting of Photodynamic Therapy Using Temporal Focusing.” Laser Physics Letters 11, 11 (September 2014): 115605 © 2014 Astro Ltd
Version
Final published version
Abstract
A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 3.0 unported license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1088/1612-2011/11/11/115605
