7.344 Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer, Fall 2010
Author(s)
Xue, Wen
Alternative Title
Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer
Date Issued
December 2010
Abstract
Cancer is a leading cause of death worldwide. Cancer involves uncontrolled cell growth, resistance to cell death, failure to differentiate into a particular cell type, and increased cellular motility. A family of gate-keeper genes, known as tumor suppressor genes, plays important roles in preventing the initiation and progression of cancer. Among these, p53 is the most famous. Because of its essential role in maintaining genomic integrity, p53 is often called the guardian of the genome. During this course, we will study how p53 serves as a pivotal tumor suppressor gene in preventing cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
tumor suppressor gene
p53
p53 protein
cancer
cell-growth signals
p53 protein
cell cycle regulation
DNA damage
DNA repair
programmed cell death
apoptosis
genome integrity
oncogenes
p53 mutations
mouse cancer models
Mdm2
microRNA
MIT Department
Massachusetts Institute of Technology. Department of Biology
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