Divergent Pathways in the Biosynthesis of Bisindole Natural Products
Name
Review- final - Jan 28.pdf
Description
Main article
Size
295.18 KB
Format
Adobe PDF
Checksum (MD5)
d30ba15b4d400b20d27c4df36146073c
Author(s)
Ryan, Katherine S.
Drennan, Catherine L
Date Issued
April 2009
Journal
Chemistry and Biology
Publisher
Elsevier
Citation
Ryan, Katherine S., and Catherine L. Drennan. “Divergent Pathways in the Biosynthesis of Bisindole Natural Products.” Chemistry & Biology 16.4 (2009) : 351-364.
Version
Author's final manuscript
Abstract
Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the “bisindoles.” Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties. Recent studies have clarified the biosynthetic construction of six bisindole molecules, revealing novel enzymatic mechanisms and leading to combinatorial synthesis of new bisindole compounds. Collectively, these results provide a vantage point for understanding how much of the diversity of the bisindole class is generated from a small number of diverging pathways from L-tryptophan, as well as enabling identification of bisindoles that are likely derived via completely distinct biosynthetic pathways.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.chembiol.2009.01.017
