Design and validation of chronic research tools for an implantable closed-loop neurostimulator
Name
757153546-MIT.pdf
Description
Full printable version
Size
12.08 MB
Format
Adobe PDF
Checksum (MD5)
59889452edf4e6a590026887b1bf2f4a
Author(s)
Shafquat, Afsah
Advisor(s)
Timothy A. Dension and Steven B. Leeb.
Date Issued
2011
Publisher
Massachusetts Institute of Technology
Abstract
Neurostimulators today provide high frequency Deep Brain Stimulation (DBS) for therapeutic modulation of diseased neural circuits. These devices are approved for the treatment of Parkinson's Disease, Essential Tremor and Dystonia, and are in clinical evaluations for Epilepsy and Depression. Despite the success of DBS therapy, the current systems are open-loop, where the clinician is the sensor and control algorithm, and hence these are programmed with stimulation parameter settings based on acute clinical observations. The need to move towards an effective closed-loop system drives the research for understanding the dynamics of the neural circuits. This work assessed the feasibility of use of a unique implantable research tool, which has sensing and algorithm technology added to an existing DBS device, for a chronic, in-vivo study of the brain state dynamics in an ovine model and presented preliminary validation of the neural interface. In addition, the sensing technology of this bi-directional neural interface was also validated using data from Brain Machine Interface studies. Finally, the work also involved development of a software tool which is a platform for analyzing neural activity datasets from different studies using machine learning techniques.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 119-120).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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