Coherent Theta Oscillations and Reorganization of Spike Timing in the Hippocampal- Prefrontal Network upon Learning
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Benchenane-2010-Coherent Theta Oscil.pdf
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Author(s)
Benchenane, Karim
Peyrache, Adrien
Khamassi, Mehdi
Gioanni, Yves
Battaglia, Francesco P.
Wiener, Sidney I.
Tierney, Patrick
Date Issued
June 2010
Journal
Neuron
Publisher
Elsevier
Citation
Benchenane, Karim, Adrien Peyrache, Mehdi Khamassi, Patrick L. Tierney, Yves Gioanni, Francesco P. Battaglia, and Sidney I. Wiener. “Coherent Theta Oscillations and Reorganization of Spike Timing in the Hippocampal- Prefrontal Network Upon Learning.” Neuron 66, no. 6 (June 2010): 921–936. © 2010 Elsevier Inc.
Version
Final published version
Abstract
To study the interplay between hippocampus and medial prefrontal cortex (Pfc) and its importance for learning and memory consolidation, we measured the coherence in theta oscillations between these two structures in rats learning new rules on a Y maze. Coherence peaked at the choice point, most strongly after task rule acquisition. Simultaneously, Pfc pyramidal neurons reorganized their phase, concentrating at hippocampal theta trough, and synchronous cell assemblies emerged. This synchronous state may result from increased inhibition exerted by interneurons on pyramidal cells, as measured by cross-correlation, and could be modulated by dopamine: we found similar hippocampal-Pfc theta coherence increases and neuronal phase shifts following local administration of dopamine in Pfc of anesthetized rats. Pfc cell assemblies emerging during high coherence were preferentially replayed during subsequent sleep, concurrent with hippocampal sharp waves. Thus, hippocampal/prefrontal coherence could lead to synchronization of reward predicting activity in prefrontal networks, tagging it for subsequent memory consolidation.
MIT Department
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2010.05.013
