Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology
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Bhatia_Mechanisms of.pdf
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Author(s)
Hauert, Sabine
Bhatia, Sangeeta N
Date Issued
July 2014
Journal
Trends in Biotechnology
Publisher
Elsevier
Citation
Hauert, Sabine, and Sangeeta N. Bhatia. “Mechanisms of Cooperation in Cancer Nanomedicine: Towards Systems Nanotechnology.” Trends in Biotechnology 32, no. 9 (September 2014): 448–455.
Version
Author's final manuscript
Abstract
Nanoparticles are designed to deliver therapeutics and diagnostics selectively to tumors. Their size, shape, charge, material, coating, and cargo determine their individual functionalities. A systems approach could help predict the behavior of trillions of nanoparticles interacting in complex tumor environments. Engineering these nanosystems may lead to biomimetic strategies where interactions between nanoparticles and their environment give rise to cooperative behaviors typically seen in natural self-organized systems. Examples include nanoparticles that communicate the location of a tumor to amplify tumor homing or self-assemble and disassemble to optimize nanoparticle transport. The challenge is to discover which nanoparticle designs lead to a desired system behavior. To this end, novel nanomaterials, deep understanding of biology, and computational tools are emerging as the next frontier.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1016/j.tibtech.2014.06.010
