Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
Name
Carneiro_MS + supplemental material.pdf
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5.03 MB
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Adobe PDF
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Author(s)
Lander, Eric Steven
Date Issued
August 2014
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Carneiro, M., C.-J. Rubin, F. Di Palma, F. W. Albert, J. Alfoldi, A. M. Barrio, G. Pielberg, et al. “Rabbit Genome Analysis Reveals a Polygenic Basis for Phenotypic Change During Domestication.” Science 345, no. 6200 (August 28, 2014): 1074–1079.
Version
Author's final manuscript
Abstract
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1253714
