Interhemispheric transfer of working memories
Name
1-s2.0-S0896627321000386-main.pdf
Description
Published version
Size
4.22 MB
Format
Adobe PDF
Checksum (MD5)
da99a95545653a1d80fc93afa7759ade
Author(s)
Brincat, Scott Louis
Donoghue, Jacob Alexander
Mahnke, Meredith K.
Kornblith, Simon
Lundqvist, Lars Mikael
Miller, Earl K
Date Issued
March 2021
Journal
Neuron
Publisher
Elsevier BV
Citation
Brincat, Scott Louis et al. "Interhemispheric transfer of working memories." Neuron 109, 6 (March 2021): P1055-1066.e4 © 2021 The Author(s)
Version
Final published version
Abstract
Visual working memory (WM) storage is largely independent between the left and right visual hemifields/cerebral hemispheres, yet somehow WM feels seamless. We studied how WM is integrated across hemifields by recording neural activity bilaterally from lateral prefrontal cortex. An instructed saccade during the WM delay shifted the remembered location from one hemifield to the other. Before the shift, spike rates and oscillatory power showed clear signatures of memory laterality. After the shift, the lateralization inverted, consistent with transfer of the memory trace from one hemisphere to the other. Transferred traces initially used different neural ensembles from feedforward-induced ones, but they converged at the end of the delay. Around the time of transfer, synchrony between the two prefrontal hemispheres peaked in theta and beta frequencies, with a directionality consistent with memory trace transfer. This illustrates how dynamics between the two cortical hemispheres can stitch together WM traces across visual hemifields.Brincat et al. use bilateral recording to show working memories transferring between the right and left prefrontal cortex. Transferred memories engage different ensembles than feedforward-induced memory traces. Trace transfer is accompanied by directed interhemispheric theta/beta synchrony.
MIT Department
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.neuron.2021.01.016
